Probiotic for Men 30 capsules

1. What Doxycycline is and what it is used for

Doxycycline belongs to a group of drugs called tetracycline antibiotics. They are used to treat many different types of infections, including:

respiratory tract infections ~ pneumonia, bronchitis, sinusitis;

urinary tract infections - inflammation of the bladder and urethra, such as cystitis, urethritis, epididymorchitis;

sexually transmitted diseases - syphilis, gonorrhea, chlamydia infection;

skin infections - acne;

eye infections;

fevers associated with lice or tick bites (including Lyme disease);

malaria when not amenable to treatment with other antimalarial drugs;

anthrax, including the pulmonary form of the infection.

Doxycycline Actavis can be used to prevent certain infections such as typhus (a serious disease caused by R. tsutsugamushi - a type of small insect), cholera, "traveller's" diarrhea, malaria, leptospirosis (a bacterial infection), anthrax, gas gangrene, tetanus and etc.

Doxycycline Actavis can be used to treat other infections not listed above and can also be combined with other products to treat your infection.

If you have any questions, please contact your doctor.

2. What you need to know before you take Doxycycline Actavis

Do not take Doxycycline Actavis:

if you are allergic to doxycycline, to any other tetracycline antibiotic, or to any of the other ingredients of this medicine (listed in section 6);

if you are pregnant or trying to become pregnant;

if you are currently breastfeeding;

in diseases of the esophagus with difficulty swallowing.

Warnings and precautions

Talk to your doctor or pharmacist before taking Doxycycline Actavis:

if you are likely to be exposed to strong sunlight or ultraviolet light (beach, solarium). Exposure to strong sunlight should be avoided while taking this medicine, as reactions of increased sensitivity of the skin to light (e.g. skin rashes) may occur.

if you have liver or kidney damage;

if you suffer from muscle weakness (a condition called myasthenia gravis);

if you know you have syphilis or another spirochetal infection (e.g. Lyme disease, leptospirosis, relapsing fever), as you may get a Jarisch-Herxheimer reaction after the antibiotic (see section 4 "Possible side effects " below);

if you are already taking a medicine called isotretinoin (used to treat acne vulgaris), as it is also known to increase intracranial pressure and its combination with doxycycline should be avoided;

if you have an autoimmune disease that causes joint pain, skin rashes and fever (systemic lupus erythematosus) your condition may get worse when you take doxycycline;

if you suffer from acid reflux. Doxycycline can make your condition worse and may not be the right medicine for you. If you experience digestive problems (throat or stomach discomfort, difficult and painful swallowing, or pain behind the sternum) while taking doxycycline, tell your doctor right away. Your doctor will advise you to stop taking doxycycline.

if you have diarrhoea, or you usually get diarrhea during antibiotic treatment, or if you suffer from stomach and bowel problems. If severe or prolonged diarrhea or bloody diarrhea occurs during treatment with doxycycline or up to two months after stopping the drug, notify your doctor immediately, as you may need to stop treatment. This may be a sign of inflammation of the colon (pseudomembranous colitis) that occurs after antibiotic treatment.

Tell your doctor right away if during treatment with doxycycline:

get a severe skin reaction (e.g. skin inflammation with redness and peeling, skin rash with itchy red spots or blisters on the skin, shedding of the surface layer of the skin all over the body). Immediately stop taking this medicine and inform your doctor, who will promptly prescribe the appropriate treatment.

get a severe headache accompanied by vomiting and visual disturbances, as your intracranial pressure may have increased. The condition resolves rapidly when treatment is discontinued, but in rare cases, permanent loss of vision has been observed. If a visual disturbance occurs during the treatment, you must be examined by an ophthalmologist. Because intracranial pressure may remain elevated for weeks after stopping treatment, your doctor should monitor you until you stabilize.

an inflammation of the vagina caused by a fungus appeared, which is manifested by itching and possibly a white discharge (vaginal candidiasis). During treatment with antimicrobial agents, incl. doxycycline, the development of microorganisms insensitive to the antibiotic (most often fungi) can be observed, which requires stopping the treatment and appointing an appropriate

Drink plenty of fluids during doxycycline treatment to reduce the risk of esophageal irritation and ulceration.

If concomitant syphilis is suspected during treatment with doxycycline, your doctor will continue to monitor you after treatment is stopped.

If you need to have blood and urine tests, you should tell them that you are taking doxycycline, as it may change some of the results.

When used for a long period of time doxycycline can cause infections that are not treated with this antibiotic. Your doctor will explain the signs and symptoms of these infections.

In case of infection with beta-hemolytic streptococci, your doctor will treat you for no less than 10 days.

Children

Although rare, doxycycline can cause effects that are reversible after the drug is stopped, such as fontanelle bombardment in infants or growth retardation of the fibula (the outer, thinner leg bone between the knee and ankle) in premature infants.

Doxycycline Actavis, as well as other products of the tetracycline group, should not be used during the period of dental development (the second half of pregnancy, infancy and in children under 8 years), as they may lead to a permanent change in the color of the developing teeth (yellow-grey-brown).

In children under 8 years of age, there may be circumstances (for example, serious or life-threatening illnesses) where your doctor may decide that the benefits outweigh the risk and doxycycline should be prescribed.

Other medicines and Doxycycline Actavis

You should tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.

Some medicines can reduce the effectiveness of Doxycycline Actavis and they are:

antacids (used for heartburn), products containing iron, calcium, zinc and bismuth. They should not be taken at the same time as doxycycline. It is recommended that they be used 1 hour before or 2 hours after taking doxycycline.

carbamazepine, phenytoin (medicines used to treat epilepsy) and barbiturates (used to treat epilepsy or as sedatives).

Doxycycline Actavis may influence the action of some medicines:

enhances the action of warfarin and coumarin anticoagulants (to prevent the formation of blood clots), which may require a reduction in their dose;

antidiabetic drugs that are taken by mouth and are derivatives of sulfonylureas;

reduces the effectiveness of beta-lactam antibiotics from the penicillin group (used to treat infections);

methoxyflurane (a type of anaesthetic) and other medicines that damage kidney function. If you are about to have surgery with general anesthesia or dental manipulation with anesthesia, you must tell the anesthesiologist or dentist that doxycycline is used, as you may experience more side effects

methotrexate - increases its toxicity;

cyclosporine A - enhances its toxic effects;

isotretinoin or other retinoids - a reversible increase in intracranial pressure is possible;

theophylline;

tubocurarine, succinylcholine and other drugs that relax skeletal muscles;

ergoalkaloids (in some cases, the appearance of ergotism is possible);

birth control pills - doxycycline can reduce the contraceptive effect and increase the chance of an unwanted pregnancy.

If you are having a blood or urine test, you must inform the laboratory that you are taking doxycycline, as it is possible to get false positive results.

Doxycycline Actavis with food, drink and alcohol

Alcohol can reduce the effect of Doxycycline Actavis. Therefore, the use of alcohol should be avoided during treatment.

Pregnancy, lactation and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to become pregnant, ask your doctor or pharmacist for advice before using this medicine.

Pregnancy

Doxycycline Actavis is contraindicated during pregnancy. The risks associated with its use during pregnancy are primarily associated with its effects on the dental and bone-skeletal development of the fetus.

Breastfeeding

Doxycycline Actavis passes into breast milk and is contraindicated for use during breastfeeding.

Driving and using machines

There is no data available to suggest that the product may affect these abilities. Given the way the drug works, no significant effects are expected.

Doxycycline Actavis contains lactose (milk sugar) and sodium

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

This medicine contains less than 1 mmol sodium (23 mg) per capsule, i.e. it can be said to be practically sodium-free.

3. How to take Doxycycline Actavis

Always take this medicine exactly as your doctor has told you. If you are not sure, ask your doctor or pharmacist.

Capsules should be taken with a large amount of liquid, in a sitting or standing position of the body and well before sleep, to reduce the risk of irritation or the appearance of ulcers on the esophagus.

It is best to take doxycycline at the same time of day.

In case of stomach irritation, it is recommended to take the medicine with food or milk.

Children aged 8 to 12 years:

In children aged 8 to 12 years, for the treatment of acute infections, doxycycline should be used when other medicines are not available or are unlikely to be effective. In such circumstances, the usual doses are:

For children weighing 45 kg or less:

First day: 4.4 mg for each kilogram of body weight (as a single or 2 divided doses), then 2.2 mg for each kilogram of body weight (as a single or 2 divided doses) from the second day. The duration of treatment depends on the infection being treated.

For more severe infections, up to 4.4 mg for each kilogram of body weight should be administered throughout the course of treatment.

For children over 45 kg - the dose for adults should be applied; 200 mg on the first day, then 100 mg daily. The duration of treatment depends on the infection being treated.

Adults and children aged 12 to 18 years:

200 mg on the first day, then 100 mg daily. The duration of treatment depends on the infection being treated.

Treatment of acne (skin infection): up to 100 mg daily (1 capsule), taken with food or liquids for 6-12 weeks.

Your doctor may prescribe doses that differ from the above, depending on the type of infection and your condition.

If your infection worsens, does not improve within a few days (except for acne), or develops a new infection, you should see your doctor again.

If you take more Doxycycline Actavis than you should

Contact your doctor or the nearest hospital immediately. If possible take the package with you so the doctor knows exactly what you have taken.

If you forget to take Doxycycline Actavis

Take the dose as soon as you remember, but if it is almost time for the next one, take the next one as prescribed. Do not take a double dose to make up for a missed dose.

If you have stopped taking Doxycycline Actavis

Do not stop taking Doxycycline Actavis throughout the course of treatment, even if you feel better. If you stop taking Doxycycline Actavis too soon, the infection may come back.

If you have any further questions related to the use of this product, please ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. If you are not sure what the side effects listed below are, ask your doctor to explain them to you.

Tell your doctor immediately if you get any of the following symptoms of an allergic reaction after taking this medicine, which may be severe:

sudden wheezing, difficulty breathing, chest tightness, fever, swelling of the eyelids, face or lips, rash or itching (especially affecting the whole body).

upset stomach, loss of appetite, severe, persistent or bloody diarrhea (even if they occurred two or three months after taking the last dose, which may be accompanied by abdominal pain or high fever). They are observed after treatment with antibiotics and can be signs of serious intestinal inflammation.

Contact your doctor as soon as possible if you experience any of the side effects listed below:

Jarisch-Herxheimer reaction, which causes high fever, chills, headache, muscle pain, and skin rash, and is usually self-limiting. It occurs soon after initiation of doxycycline treatment in infections caused by spirochetes, eg Lyme disease.

skin rash, peeling or peeling of the skin;

severe skin reactions that make you feel very sick;

skin that is more sensitive to sunlight than normal. You may get a skin rash, itching, redness or severe sunburn. If this happens, stop taking the medicine and tell your doctor.

fever, swollen lymph nodes or skin rash. These may be symptoms of a condition known as DRESS (drug rash with eosinophilia and systemic symptoms), which can be severe and life-threatening.

headache, which, if very severe, may be associated with visual disturbances, such as blurred vision or vision loss;

inflammation and/or ulcers of the esophagus (occurring with difficult and painful swallowing, pain behind the sternum and indigestion);

blood disorders due to changes in the number of certain types of cells in the blood. I can symptoms

Common (may affect up to 1 in 10 patients):

hypersensitivity reactions, including anaphylactic and anaphylactoid reactions (severe allergic reactions that may cause difficulty breathing or dizziness) and anaphylactic shock (severe allergic reaction with a sharp drop in blood pressure, urticarial rash and difficulty breathing), angioneurotic edema (severe allergic reaction with swelling of the face or throat), anaphylactoid purpura (point-like hemorrhages, most often subcutaneous), exacerbation of symptoms of systemic lupus erythematosus (a disorder of the immune system with joint pain, skin rashes and fever), inflammation of the lining of the heart , serum sickness (proceeds with rash, itching, general malaise, low blood pressure, swollen and painful lymph nodes, joint pain, inflammation of the kidneys), shortness of breath, rapid pulse, low blood pressure, swelling of the limbs, urticaria;

photosensitivity reactions (increased sensitivity to light);

skin rashes (including maculopapular and erythematous);

headache;

nausea/vomiting.

Uncommon (may affect up to 1 in 100 patients):

indigestion (acids/gastritis).

Rare (may affect up to 1 in 1,000 patients):

hemolytic anemia (a decrease in the number of red blood cells, which may cause pale or yellowing of the skin, weakness or shortness of breath), thrombocytopenia (a decrease in the number of platelets, which increases the risk of bleeding or bruising), neutropenia (a decrease in the number of white blood cells), eosinophilia (increased number of eosinophils - a type of blood cell);

drug rash with an increase in the number of eosinophil cells in the blood (DRESS); fever that occurs immediately after the start of treatment with doxycycline and with spirochete infections (Yarish-Herxheimer reaction) - characterized by repeated attacks of high fever, headache, muscle and joint pain, nausea and skin rash and is due to endotoxins, which are released by the spirochetes that are killed by the action of the antibiotic;

brown-black staining of the thyroid gland, which is established under a microscope, without damage to the function of the thyroid gland;

decreased appetite or loss of appetite;

benign increase in blood pressure in adolescents and adults who have taken the full therapeutic dose (proceeds with blurred vision, dark spots in front of the eyes, double vision - there are also reports of permanent vision loss; in infants, "bombing" of the fontanelle is observed); visual disturbances; noise in the ears;

sudden flushing of the face;

inflammation of the pancreas (pancreatitis), diarrhea caused by the multiplication of clostridia, which can become very severe and life-threatening (pseudomembranous colitis), inflammation and ulcers of the esophagus (occurring with painful and difficult swallowing, pain behind the sternum), pain in abdominal area, inflammation of the rectum, diarrhea, difficulty swallowing, inflammation of the tongue;

intestinal inflammation* inflammation around the anus and genitals (most often caused by fungi), with itching;

liver damage with a transient increase in functional liver parameters;

inflammation of the liver and jaundice; abnormal values of liver function tests;

severe skin reactions, such as exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (the last two are accompanied by blistering of the skin, mouth, eyes and genitals and can be life-threatening); increased skin pigmentation;

photoonycholysis (separation and loosening of the nail from the nail bed after exposure to the sun, sometimes accompanied by a change in the color of the nail); joint and muscle pain;

increase in blood urea (kidney function test);

inflammation of the vagina.

Not known (frequency cannot be estimated from the available data):

black "hairy" tongue;

tooth discoloration and/or lack of tooth growth.

5. How to store Doxycycline Actavis

To be stored below 25°C.

To be stored in the original packaging.

Keep out of the reach of children.

Do not use this medicine after the expiry date which is stated on the carton. The expiration date corresponds to the last day of the specified month.

Do not dispose of medicines down the drain or in the household waste container. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help protect the environment.

6. Contents of the package and additional information

What Doxycycline Actavis contains:

The active substance is doxycycline hyclate, equivalent to 100 mg of doxycycline.

The other ingredients are: corn starch, alginic acid, sodium lauryl sulfate, lactose monohydrate, magnesium stearate; Composition of the hard gelatin capsule: indigo xapMHH-FD&C blue 2 (E 132), quinoline yellow (E 104); titanium dioxide (E171), gelatin

What Doxycycline Actavis looks like and what the pack contains:

Hard cylindrical gelatin capsules

6 capsules each in a PVC/AI foil blister.

1 blister in a cardboard box.